About Tesamorelin 10 Mg
Tesamorelin is a synthetic 44-amino acid peptide analogue of Growth Hormone-Releasing Hormone (GHRH), also known as a growth hormone-releasing factor (GRF) analog.
It is primarily used to reduce excess visceral (deep abdominal) fat in adults with HIV-associated lipodystrophy. It is the first medication specifically approved for this purpose.
Chemical Description
- It consists of the full 44-amino acid sequence of human GHRH, modified at the N-terminus with a trans-3-hexenoyl group attached to the tyrosine residue. This modification enhances its stability and resistance to enzymatic breakdown.
- Molecular Formula (free base): CHNOS
- Molecular Weight: Approximately 5,136 g/mol
- It is typically supplied as tesamorelin acetate for subcutaneous injection.
Mechanism of Action
Tesamorelin binds to GHRH receptors in the pituitary gland, stimulating the natural pulsatile release of endogenous growth hormone (GH). This increases levels of insulin-like growth factor-1 (IGF-1), which promotes lipolysis (fat breakdown), particularly targeting visceral abdominal fat, while supporting overall body composition regulation.
Key Uses
- Reduction of excess abdominal fat in HIV patients with lipodystrophy.
- It is administered as a daily subcutaneous injection, typically 2 mg into the abdomen.
Common Side Effects
- Injection site reactions (redness, swelling, itching, pain)
- Joint or muscle pain
- Fluid retention (edema)
- Itching or tingling sensations
- Possible changes in blood sugar or IGF-1 levels
Tesamorelin is generally well-tolerated when used as prescribed. It is a prescription medication and should only be used under medical supervision.
Optimized Purity and FormulationWith a stated purity of 99%, Tesamorelin offers a dependable choice for laboratories engaged in peptide research. Delivered as a white or off-white lyophilized powder, it comes in sterile glass vials and is designed with research accuracy in mind. Every batch is clearly labeled with CAS number, molecular formula, and expiry to ensure traceability and reliability.
Designed for Reliable Experimental UseThis product is formulated for both in vitro and in vivo studies under appropriately approved protocols. It is suitable for adult research models and has a molecular composition conducive to growth hormone pathway studies. Tesamorelin is renowned for its stability post-reconstitution-use within 7-14 days when stored at 2-8C-to assure experimental consistency.
Storage and Handling Made SimpleTesamorelin should be stored refrigerated (2-8C), shielded from light, and handled per standard peptide procedures. After reconstitution with bacteriostatic water, prompt usage ensures optimal activity. Always refer to the specific manufacturer's guidance for batch-related details such as expiry and packaging.
FAQ's of Tesamorelin 10 Mg:
Q: How should Tesamorelin 10 mg be reconstituted for laboratory use?
A: Reconstitute the lyophilized Tesamorelin powder using bacteriostatic water or as directed by your laboratory protocol. Swirl the vial gently to dissolve the powder completely without shaking.
Q: What is the recommended storage condition for Tesamorelin both before and after reconstitution?
A: Prior to reconstitution, store the vials refrigerated at 2-8C and protect them from light. After reconstitution, the solution remains stable and should be used within 7-14 days, also kept refrigerated within that temperature range.
Q: When should Tesamorelin be used after reconstitution to maintain its efficacy?
A: For optimal performance in research, use the reconstituted solution within 7-14 days if stored properly between 2-8C, to ensure peptide stability and reliability in experiments.
Q: Where is Tesamorelin primarily applied, and who should use it?
A: Tesamorelin is exclusively intended for research use-in vitro or in vivo studies within laboratory or clinical research settings. It should only be handled by trained professionals under approved protocols, not for general human consumption or self-administration.
Q: What processes are involved in preparing Tesamorelin for experimental application?
A: After ensuring the product is within its expiry and stored correctly, reconstitute as instructed, dilute per experimental requirements, and administer according to the research protocol. Proper aseptic technique and documentation are recommended throughout.
Q: What are the main benefits of using Tesamorelin in research?
A: Tesamorelin serves as a reliable analog for studying growth hormone release mechanisms, supporting research into metabolic conditions and the development of potential therapies, especially where growth hormone modulation is relevant.